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发布时间: 2016-03-11 17:39:10   作者:本站编辑   来源: 本站原创   浏览次数:



袁若,男,教授,博士生导师,西南大学化学化工学院院长,发光与实时分析教育部重点实验室副主任,《Scientific Reports》编委1994年获湖南大学化学化工学院分析化学专业博士学位,此后在湖南大学化学生物传感与计量学国家重点实验室工作,主要从事生物和化学传感器的研究;先后在香港浸会大学、日本大阪大学和香港城市大学做访问学者,1999年至今在西南大学化学化工学院工作。近年来,作为项目负责人主持完成及在研的国家及部省级科研课题20余项,主要从事以功能纳米材料与免疫、适体及DNAMicroRNA及细胞结合研制电致化学发光、电化学、光致电化学生物传感器,用于疾病标志物及肿瘤细胞检测和抗肿瘤药效评价。在国际刊物(如《Anal. Chem.》、《Chem.-Eur. J》、《Chem. Commun.》、《Andv. Funct. Mater.》、《Biomaterials》、《Small》、《J. Mater. Chem. A》、《Nanoscale》、《ACS Appl. Mater. Interfaces》、《Biosens. Bioelectron.》等)上发表了SCI 收录论文400余篇,SCI收录他引次数8000余次。指导的一名博士研究生2010年获全国优秀博士论文提名,研究成果获重庆市2012年度自然科学一等奖(排名第一),重庆市2013年度科技进步一等奖(排名第二),入选Elsevier发布的20142015年中国高被引学者(Most Cited Chinese Researchers)榜单。


1.      Wnag, H.J.; Yuan, Y.L.; Zhuo, Y; Chai, Y.Q.*; Yuan, R.*.Self-Enhanced Electrochemiluminescence Nanorods of Tris(bipyridine) Ruthenium(II) Derivative and Its Sensing Application for Detection of N‑Acetyl-β‑D‑glucosaminidase. Anal. Chem., 2016, 88, 2258-2265.

2.      Han, J.; Zhuo, Y*.; Chai, Y.Q.; Xiang, Y.; Yuan, R.*. New type of redox nanoprobe: C60-based nanomaterial and its application in electrochemical immunoassay for doping detection. Anal. Chem., 2015, 87(3), 1669-1675.

3.      Zhang, P.; Wu, X.Y.; Yuan, R*; Chai, Y.Q.*. An "Off On" Electrochemiluminescent Biosensor Based on DNAzyme-Assisted Target Recycling and Rolling Circle Amplifications for Ultrasensitive Detection of microRNA. Anal.  Chem., 2015, 87(6), 3202-3207.

4.      Chen, A.Y.; Gui, G.F.; Zhuo, Y*.; Chai, Y.Q.; Xiang, Y.; Yuan, R.*. Signal-off Electrochemiluminescence Biosensor Based on Phi29 DNA Polymerase Mediated Strand Displacement Amplification for MicroRNA Detection. Anal. Chem., 2015, 87(12), 6328-6334.

5.      Zhao, M.; Liao, N.; Zhuo, Y.*; Chai, Y.Q.; Wang, J.P.; Yuan, R.*. Triple Quenching of a Novel Self-Enhanced Ru(II) Complex by Hemin/G-Quadruplex DNAzymes and Its Potential Application to Quantitative Protein Detection. Anal. Chem.. 2015, 87(15), 7602-7609.

6.      Zhang, P.; Zhuo, Y.; Chang, Y.Y.; Yuan, R.*; Chai, Y.Q.*. Electrochemiluminescent Graphene Quantum Dots as a Sensing Platform: A Dual Amplification for MicroRNA Assay. Anal. Chem., 2015, 87(20), 10385-10391.

7.      Xie, S.B.; Yuan, Y.L.; Chai, Y.Q.*; Yuan, R.*. Tracing Phosphate Ions Generated during Loop-Mediated Isothermal Amplification for Electrochemical Detection of Nosema bombycis Genomic DNA PTP1.. Anal.Chem., 2015, 87(20), 10268-10274.

8.      Shen,W.J. Zhuo, Y.* Chai, Y.Q. Yuan, R.*.Cu-Based Metal−Organic Frameworks as a Catalyst To Construct a Ratiometric Electrochemical Aptasensor for Sensitive Lipopolysaccharide Detection. Anal. Chem., 2015, 87(22), 11345-11352.

9.      Liang, W.B.; Zhuo, Y,; Xiong,C.Y.; Zheng,Y.N.; Chai, Y.Q*.; Yuan, R.*.Ultrasensitive Cytosensor Based on Self-enhanced Electrochemiluminescent Ruthenium-Silica Composite Nanoparticles for Efficient Drug Screening with Cell Apoptosis Monitoring.Anal. Chem., 2015,87(24)12363-12371.

10.  Gui, G.F.; Zhuo, Y.*; Chai, Y.Q.; Xiang, Y.; Yuan, R.*. In situ generation of self-enhanced luminophore by β lactamase catalysis for highly sensitive electrochemiluminescent aptasensor. Anal. Chem., 2014, 86, 5873-5880.

11.  Zhuo, Y.*; Liao, N.; Chai, Y.Q.;Gui, G.F.; Zhao, M.; Han, J.; Xiang, Y.; Yuan, R.*. Ultrasensitive apurinic/apyrimidinic endonuclease 1 immunosensing based on self-enhanced electrochemiluminescence of a Ru(II) complex. Anal. Chem., 2014, 86, 1053-1060.

12.  Xiong, C.Y.;  Wang, H.J.;  Liang, W.B.;  Yuan, Y.L.; Yuan,R.*; Chai, Y.Q.*. Luminescence-Functionalized Metal–Organic Frameworks Based on a Ruthenium(II) Complex: A Signal Amplification Strategy for Electrogenerated Chemiluminescence Immunosensors. Chem. Eur. J. 2015, 21(27), 9825-9832.

13.  Yuan, Y.L.; Yuan, R.*; Chai, Y.Q.; Zhuo, Y.; Gan, X.X.; Bai, L.J.. 3,4,9,10-perylenetetracarboxylic acid/hemin nanocomposites act as redox probes and electrocatalysts for constructing a pseudobienzyme-channeling amplified electrochemical aptasensor.  Chem. -  Eur. J., 2012, 18(44), 14186-14191.

14.  Xie, S.B.; Zhang, J.*; Yuan, Y.L.; Chai, Y.Q.; Yuan, R.*. An electrochemical peptide cleavage-based biosensor for prostate specific antigen detection via host-guest interaction between ferrocene and beta-cyclodextrin. Chem. commun., 2015, 51(16), 3387-3390.

15.  Xie, H; Zhang, QQ; Wang, Q; Chai, YQ; Yuan, YL*; Yuan, R*. Fe3O4NPs mediated nonenzymatic electrochemical immunosensor for the total protein of Nosema bombycis detection without addition of substrate. Chem. Commun., 2015, 51(33), 7132-7135.

16.  Chang, Y.Y.; Xie, S.B.; Chai, Y.Q.*; Yuan, Y.L.; Yuan, R*. 3,4,9,10-Perylenetetracarboxylic acid/o-phenylenediamine nanomaterials as novel redox probes for electrochemical aptasensor systems based on an Fe3O4 magnetic bead as a nonenzymatic catalyst. Chem. Commun., 2015, 51(36), 7657-7660.

17.  Wang, D. Zheng, Y.N.; Chai, Y.Q. .; Yuan, Y.L.*; Yuan, R.*. Target protein induced cleavage of a specific peptide for prostate-specific antigen detection with positively charged gold nanoparticles as signal enhancer. Chem. Commun., 2015, 51(52), 10521-10523.

18.  Xu, Z.Q.; Dong, Y.W.; Li, J.Y.; Yuan, R.*. A ferrocene-switched electrochemiluminescence "off-on'' strategy for the sensitive detection of cardiac troponin I based on target transduction and a DNA walking machine. Chem. Commun., 2015, 51(76), 14369-14372.

19.  Zhou, Y.; Zhuo, Y.; Liao, N.; Chai, Y.Q.*; Yuan, R*. Ultrasensitive immunoassay based on a pseudobienzyme amplifying system of choline oxidase and luminol-reduced Pt@Au hybrid nanoflowers. Chem. Commun., 2014, 50(93), 14627-14630.

20.  Xie, S.B.; Yuan, Y.L.; Song, Y.; Zhuo, Y.; Li, T.; Chai, Y.Q.*; Yuan, R*. Using the ubiquitous pH meter combined with a loop mediated isothermal amplification method for facile and sensitive detection of Nosema bombycis genomic DNA PTP1. Chem. Commun., 2014, 50(100), 15932-15935.

21.  Han, J.; Zhuo, Y.*; Chai, Y.Q.; Yuan, R.*. Dual-responses for electrochemical and electrochemiluminescent detection based on a bifunctional probe. Chem. Commun., 2014, 50, 3367-3369.

22.  Xie, S.B.; Chai, Y.Q.*; Yuan, Y.L; Yuan, R.*. Manganese porphyrin-double stranded DNA complex guided in situ deposition of polyaniline for electrochemical thrombin detection, Chem. Commun., 2014,50, 7169-7172.

23.  Chen, Y.; Wang, ; Xu, J.; Xiang, Y.*; Yuan, R.*; Chai, Y.Q.. A new hybrid signal amplification strategy for ultrasensitive electrochemical detection of DNA based on enzyme-assisted target recycling and DNA supersandwich assemblies. Chem. Commun., 2013, 49(20), 2052-2054.

24.  Yuan, Y.L.; Chai, Y.Q.*; Yuan, R.*; Zhuo, Y.; Gan, X.X.. An ultrasensitive electrochemical aptasensor with autonomous assembly of hemin-G-quadruplex DNAzyme nanowires for pseudo triple-enzyme cascade electrocatalytic amplification. Chem. Commun., 2013, 49(66), 7328-7330.

25.  Li, Y.; Zhong, Z.Y.; Chai, Y.Q.; Song, Z.J.; Zhuo, Y.; Su, H.L.; Liu, S.M.; Wang, D.*; Yuan, R.*.  Simultaneous electrochemical immunoassay of three liver cancer biomarkers using distinguishable redox probes as signal tags and gold nanoparticles coated carbon nanotubes as signal enhancers. Chem. Commun., 2012, 48, 537–539.

26.  Zhong, X.; Yuan, R.*, Chai, Y.Q. In situ spontaneous reduction synthesis of spherical Pd@Cys-C60 nanoparticles and its application in nonenzymatic glucose biosensors. Chem. Commun., 2012, 48(4), 597–599.

27.  Yuan, Y.L.; Yuan, R.*; Chai, Y.Q.; Zhuo, Y,; Ye, X.Y; Gan, X.X.; Bai, L.J.. Hemin/G-quadruplex simultaneously acts as NADH oxidase and HRP-mimicking DNAzyme for simple, sensitive pseudobienzyme electrochemical detection of thrombin. Chem. Commun., 2012, 48(38), 4621–4623.

28.  Liao, N.; Zhuo, Y.*; Chai, Y.Q.; Xiang, Y.; Cao, Y.L.; Yuan, R.*; Han, J.. Amplified electrochemiluminescent immunosensing using apoferritin-templated poly(ethylenimine) nanoparticles as co-reactant. Chem. Commun., 2012, 48(61), 7610-7612.

29.  Bai, L.J.; Yuan, R.*; Chai, Y.Q.; Yuan, Y.L.; Wang, Y.; Xie, S.B.. Direct electrochemistry and electrocatalysis of a glucose oxidase-functionalized bioconjugate as a trace label for ultrasensitive detection of thrombin. Chem. commun., 2012, 48(89), 10972-10974.

30.  Wang, H.J.; Yuan, Y.L .; Chai, Y.Q.*; Yuan, R.*. Sandwiched Electrochemiluminescent Peptide Biosensor for the Detection of Prognostic Indicator in Early-Stage Cancer Based on Hollow, Magnetic, and Self-Enhanced Nanosheets. Small, 2015, 11(30), 3703-3709.

31.  Wang, H.J.; Bai, L.J.;  Chai, Y.Q.*;  Yuan, R.*.Synthesis of multi-fullerenes encapsulated palladium  nanocage, and its application in electrochemiluminescence immunosensors for the detection of streptococcus suis serotype. Small 2014, 10(9), 1857-1865.

32.  Zhao, M; Zhuo, Y*; Chai, YQ; Yuan, R*. Au nanoparticles decorated C-60 nanoparticle-based label-free electrochemiluminesence aptasensor via a novel "on-off-on" switch system. Biomaterials, 2015, 52, 476-483.

33.  Bai, L.J.; Yuan, R.*; Chai, Y.Q.; Zhuo, Y.; Yuan, Y.L.; Wang, Y..  Simultaneous electrochemical detection of multiple analytes based on dual signal amplification of single-walled carbon nanotubes and multi-labeled graphene sheets. Biomaterials, 2012, 33(4),1090-1096.

34.  Ma, J.J.; Wang, H.J.; Yang, X.*; Chai, Y.Q.; YuanR.*.Porous carbon-coated CuCo2O4 concave polyhedrons derived from metal–organic frameworks as anodes for lithium-ion batteries. J. Mater. Chem. A, 2015, 3(22), 12038-12043.

35.  Chen, Y.; Xiang, Y.*; Yuan, R.*; Chai Y. Q. A restriction enzyme-powered autonomous DNA walking machine: its application for a highly sensitive electrochemiluminescence assay of DNA. Nanoscale, 2015, 7, 981–986.

36.  Xie, S. B; Ye, J.W.; Yuan, Y.L.; Chai, Y.Q.*; Yuan, R.*.A multifunctional hemin@metal-organic framework and its application to construct an electrochemical aptasensor for thrombin detection. Nanoscale, 2015, 7(43), 18232-18238.

37.  Chen, Y., Yang, M.L.; Xiang, Y.*; Yuan, R.*; Chai, Y,Q..Binding-induced autonomous disassembly of aptamer–DNAzyme supersandwich nanostructures for sensitive electrochemiluminescence turn-on detection of ochratoxin A. Nanoscale, 2014, 6, 1099–1104.

38.  Wu, X.Y.; Chai, Y.Q.*; Zhang, P.; Yuan, R.*. An electrochemical biosensor for sensitive detection of microrna-155: combining target recycling with cascade catalysis for signal amplification. ACS Appl. Mater. Inter., 2015, 7(1), 713-720.

39.  Shen, W.J.; Zhuo, Y*; Chai, Y.Q.; Yang, Z.H.; Han, J; Yuan, R*. Enzyme-Free Electrochemical Immunosensor Based on Host-Guest Nanonets Catalyzing Amplification for Procalcitonin Detection. ACS Appl. Mater. Inter., 2015, 7(7), 4127-4134.

40.  Yang, Z.H.; Zhuo, Y.; Yuan, R.*; Chai, Y.Q.*. Amplified Thrombin Aptasensor Based on Alkaline Phosphatase and Hemin/G-Quadruplex-Catalyzed Oxidation of 1-Naphthol.ACS Appl. Mater. Inter., 2015, 7(19), 10308-10315.

41.  He, Y.; Xie, S.B.; Yang, X.; Yuan, R.*; Chai, Y.Q.*.Electrochemical Peptide Biosensor Based on in Situ Silver Deposition for Detection of Prostate Specific Antigen. ACS Appl. Mater. Inter., 2015, 7(24), 13360-13366.

42.  Yang, F.; Yang, Z.H.; Zhuo, Y.; Chai, Y.Q.*; Yuan, R.*. Ultrasensitive electrochemical immunosensor for carbohydrate antigen 19-9 using Au/porous graphene nanocomposites as platform and Au@Pd core/shell bimetallic functionalized graphene nanocomposites as signal enhancers. Biosens. Bioelectron., 2015, 66, 356-362.

43.  Zhu, Q.; Chai, Y.Q.*; Zhuo, Y.; Yuan, R.*. Ultrasensitive simultaneous detection of four biomarkers based on hybridization chain reaction and biotin-streptavidin signal amplification strategy.Biosens. Bioelectron.,2015, 68, 42-48.

44.  Wang, H.J.; Yuan, Y.L.; Chai, Y.Q.*; Yuan, R.*. Self-enhanced electrochemiluminescence immunosensor based on nanowires obtained by a green approach.Biosens. Bioelectron.,2015, 68, 72-77.

45.  Wang, Q.; Song Y.; Chai, Y.Q.; Pan, G.Q.; Li, T.; Yuan, Y.L.*; Yuan, R.*. Electrochemical immunosensor for detecting the spore wall protein of Nosema bombycis based on the amplification of hemin/G-quadruplex DNAzyme concatamers functionalized Pt@Pd nanowires. Biosens. Bioelectron., 2014, 60, 118-123.

46.  Zhang, J.; Yuan, Y.L.; Xie, S.B.; Chai, Y.Q.*, Yuan, R.*.Amplified amperometric aptasensor for selective detection of protein using catalase-functional DNA-PtNPs dendrimer as a synergetic signal amplification label. Biosens. Bioelectron.,2014, 60, 224-230.

47.  Cao, S.R.; Zhang, L.; Chai, Y.Q.; Yuan, R.*. An integrated sensing system for detection of cholesterol based on TiO2-graphene-Pt-Pd hybrid nanocomposites. Biosens. Bioelectron., 2013. 42, 532-538.

48.  Han, J.; Zhuo, Y.*; Chai, Y.Q.; Xiang, Y.; Yuan, R.*; Yuan, Y.L.; Liao, N.. Ultrasensitive electrochemical strategy for trace detection of APE-1 via triple signal amplification strategy. Biosens. Bioelectron., 2013, 41,116-122.

49.  Wang, H.J.; Yuan, R.*; Chai, Y.Q.*; Cao, Y.L.; Gan, X.X.; Chen, Y.F.; Wang, Y.. An ultrasensitive peroxydisulfate electrochemiluminescence immunosensor for Streptococcus suis serotype 2 based on L-cysteine combined with mimicking bi-enzyme synergetic catalysis to in situ generate coreactant. Biosens. Bioelectron., 2013, 4363-68.

50.  Yuan, Y.L.; Liu, G.P.; Yuan, R.*; Chai, Y.Q.*; Gan, X.X.; Bai, L.J..  Dendrimer functionalized reduced graphene oxide as nanocarrier for sensitive pseudobienzyme electrochemical aptasensor. Biosens. Bioelectron.,2013. 42, 474-480.

51.  Zhu, Q.; Chai, Y.Q.*; Yuan, R.*; Zhuo, Y.; Han, J.; Li, Y.; Liao, N.. Amperometric immunosensor for simultaneous detection of three analytes in one interface using dual functionalized graphene sheets integrated with redox-probes as tracer matrixes. Biosens. Bioelectron.,2013, 43,440-445.

52.  Han, J; Zhuo, Y.*; Chai, YQ; Gui, GF; Zhao, M; Zhu, Q; Yuan, R*.A signal amplification strategy using the cascade catalysis of gold nanoclusters and glucose dehydrogenase for ultrasensitive detection of thrombin. Biosens. Bioelectron.,2013, 50, 161-166.

53.  Bai, L.J.; Chai, Y.Q.*; Yuan, R.*; Yuan, Y.L.; Xie, S.B.; Jiang, L.P. Amperometric aptasensor for thrombin detection using enzyme-mediated direct electrochemistry and DNA-based signal amplification strategy. Biosens. Bioelectron., 2013, 50, 325-330.

54.  He, Y.; Chai, Y.Q.*; Yuan, R.*; Wang, H.J.; Bai, L.J.; Cao, Y.L.; Yuan, Y.L..An ultrasensitive electrochemiluminescence immunoassay based on supersandwich DNA structure amplification with histidine as a co-reactant.Biosens. Bioelectron., 2013, 50, 294-299.

55.  Liao, N.; Zhuo, Y.*; Chai, Y.Q.; Xiang, Y.; Han, J.; Yuan, R.*. Reagent less electrochemiluminescent detection of protein biomarker using graphene-based magnetic nanoprobes and poly-L-lysine as co-reactant. Biosens. Bioelectron., 2013, 45, 189-194.

56.  Zhang, M.H.; Yuan, R.; Chai, Y.Q.; Chen, S.H.; Zhong, H.A.; Wang, C.; Cheng, Y.F.. A biosensor for cholesterol based on gold nanoparticles-catalyzed luminol electrogenerated chemiluminescence. Biosens. Bioelectron., 2012, 32(1), 288- 292.

57.  Cao, Y.L.; Yuan, R.; Chai, Y.Q.; Mao, L.; Niu, H.; Liu, H.J.; Zhuo, Y.. Ultrasensitive luminol electrochemiluminescence for protein detection based on in situ generated hydrogen peroxide as coreactant with glucose oxidase anchored AuNPs@MWCNTs labeling. Biosens. Bioelectron., 2012, 31(1), 305- 309.

58.  Gan, X.X.; Yuan, R.*; Chai, Y.Q.; Yuan, Y.L; Mao, L.; Cao, Y.L.; Liao, Y.H.. 4-(Dimethylamino) butyric acid@PtNPs as Enhancer for Solid-State Electrochemiluminescence Aptasensor Based on Target-Induced Strand Displacement. Biosens. Bioelectron., 2012, 34, 25-29.

59.  Wang, H.J.; Yuan, R.*; Chia, Y.Q.; Niu, H.; Cao, Y.L.; Liu, H.J.. Bi-enzyme synergetic catalysis to in situ generate coreactant of peroxydisulfate solution for ultrasensitive electrochemiluminescence immunoassay. Biosens. Bioelectron., 2012, 37(1), 6–10.

60.  Su, H.L.; Yuan, R.*; Chai, Y.Q.; Zhuo, Y.. Enzyme-nanoparticle conjugates at oil–water interface for amplification of electrochemical immunosensing.  Biosens. Bioelectron., 2012, 33(1), 288-292.