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发布时间: 2015-12-22 14:25:46   作者:本站编辑   来源: 本站原创   浏览次数:


柴雅琴  教授,196211月出生,19847月毕业于辽宁师范大学化学系并获理学学士学位; 19877月毕业于东北师范大学化学系并获理学硕士学位;2004年毕业西南师范大学化学化工学院并获理学博士学位。1999-2000在香港城市大学生物及化学系做访问学者。近五年来主持1项国家自然科学基金和1项重庆市自然基金重点项目,参加2项国家自然科学基金面上项目。主要从事电化学、电致化学发光生物传感器的研究。在国际重要刊物(如《Anal. Chem.》、《Chem.-Eur. J》、《Chem. Commun.》、《Biomaterials》、《Small》、《Nanoscale》、《ACS Appl. Mater. Interfaces》、《Biosens. Bioelectron.》等)上发表了SCI 论文81篇,其中影响因子大于5.0论文37篇;获授权国家发明专利1项。科研成果获2012年度重庆市自然科学一等奖1项(排名第二)。


1.      Zhang, P.; Wu, X.Y.; Yuan, R*; Chai, Y.Q.*. An "Off On" Electrochemiluminescent Biosensor Based on DNAzyme-Assisted Target Recycling and Rolling Circle Amplifications for Ultrasensitive Detection of microRNA. Anal.  Chem., 2015, 87(6), 3202-3207.

2.      Zhang, P.; Zhuo, Y.; Chang, Y.Y.; Yuan, R.*; Chai, Y.Q.*. Electrochemiluminescent Graphene Quantum Dots as a Sensing Platform: A Dual Amplification for MicroRNA Assay. Anal. Chem., 2015, 87(20), 10385-10391.

3.      Ma, M.N.; Zhuo, Y.* Yuan, R. Chai, Y.Q.* New Signal Amplification Strategy Using Semicarbazide as Coreaction Accelerator for Highly Sensitive Electrochemiluminescent Aptasensor Construction.Anal. Chem., 2015, 87(22), 11389-11397.

4.      Xie, S.B.; Yuan, Y.L.; Chai, Y.Q.*; Yuan, R.*. Tracing Phosphate Ions Generated during Loop-Mediated Isothermal Amplification for Electrochemical Detection of Nosema bombycis Genomic DNA PTP1.. Anal.Chem., 2015, 87(20), 10268-10274.

5.      Liang, W.B.; Zhuo, Y,; Xiong,C.Y.; Zheng,Y.N.; Chai, Y.Q*.; Yuan, R.*.Ultrasensitive Cytosensor Based on Self-enhanced Electrochemiluminescent Ruthenium-Silica Composite Nanoparticles for Efficient Drug Screening with Cell Apoptosis Monitoring.Anal. Chem., 2015,87(24)12363-12371.

6.      Xiong, C.Y.;  Wang, H.J.;  Liang, W.B.;  Yuan, Y.L.; Yuan,R.*; Chai, Y.Q.*. Luminescence-Functionalized Metal–Organic Frameworks Based on a Ruthenium(II) Complex: A Signal Amplification Strategy for Electrogenerated Chemiluminescence Immunosensors. Chem. Eur. J. 2015, 21(27), 9825-9832.

7.      Chang, Y.Y.; Xie, S.B.; Chai, Y.Q.*; Yuan, Y.L.; Yuan, R.*. 3,4,9,10-Perylenetetracarboxylic acid/o-phenylenediamine nanomaterials as novel redox probes for electrochemical aptasensor systems based on an Fe3O4 magnetic bead as a nonenzymatic catalyst. Chem. Commun., 2015, 51(36), 7657-7660.

8.      Zhou, Y.; Zhuo, Y.; Liao, N.; Chai, Y.Q.*; Yuan, R*. Ultrasensitive immunoassay based on a pseudobienzyme amplifying system of choline oxidase and luminol-reduced Pt@Au hybrid nanoflowers. Chem. Commun., 2014, 50(93), 14627-14630.

9.      Xie, S.B.; Yuan, Y.L.; Song, Y.; Zhuo, Y.; Li, T.; Chai, Y.Q.*; Yuan, R*. Using the ubiquitous pH meter combined with a loop mediated isothermal amplification method for facile and sensitive detection of Nosema bombycis genomic DNA PTP1. Chem. Commun., 2014, 50(100), 15932-15935.

10.  Xie, S.B.; Chai, Y.Q.*; Yuan, Y.L; Yuan, R.*. Manganese porphyrin-double stranded DNA complex guided in situ deposition of polyaniline for electrochemical thrombin detection, Chem. Commun., 2014,50, 7169-7172.

11.  Wang, H.J.; Yuan, Y.L .; Chai, Y.Q.*; Yuan, R.*. Sandwiched Electrochemiluminescent Peptide Biosensor for the Detection of Prognostic Indicator in Early-Stage Cancer Based on Hollow, Magnetic, and Self-Enhanced Nanosheets. Small, 2015, 11(30), 3703-3709.

12.  Wang, H.J.; Bai, L.J.;  Chai, Y.Q.*;  Yuan, R.*.Synthesis of multi-fullerenes encapsulated palladium  nanocage, and its application in electrochemiluminescence immunosensors for the detection of streptococcus suis serotype. Small 2014, 10(9), 1857-1865.

13.  Ma, M.N.; Zhang, X.; Zhuo, Y*.; Chai, Y.Q.*; Yuan, R.. An amplified electrochemiluminescent aptasensor using Au nanoparticles capped by 3,4,9,10-perylene tetracarboxylic acid-thiosemicarbazide functionalized C60 nanocomposites as a signal enhancement tag. Nanoscale, 2015, 7(5), 2085-2092.

14.  Xie, S. B; Ye, J.W.; Yuan, Y.L.; Chai, Y.Q.*; Yuan, R.*.A multifunctional hemin@metal-organic framework and its application to construct an electrochemical aptasensor for thrombin detection. Nanoscale, 2015, 7(43), 18232-18238.

15.  Wu, X.Y.; Chai, Y.Q.*; Zhang, P.; Yuan, R.*. An electrochemical biosensor for sensitive detection of microrna-155: combining target recycling with cascade catalysis for signal amplification. ACS Appl. Mater. Inter., 2015, 7(1), 713-720.

16.  Yang, Z.H.; Zhuo, Y.; Yuan, R.*; Chai, Y.Q.*. Amplified Thrombin Aptasensor Based on Alkaline Phosphatase and Hemin/G-Quadruplex-Catalyzed Oxidation of 1-Naphthol.ACS Appl. Mater. Inter., 2015, 7(19), 10308-10315.

17.  He, Y.; Xie, S.B.; Yang, X.; Yuan, R.*; Chai, Y.Q.*.Electrochemical Peptide Biosensor Based on in Situ Silver Deposition for Detection of Prostate Specific Antigen. ACS Appl. Mater. Inter., 2015, 7(24), 13360-13366.

18.  Yang, F.; Yang, Z.H.; Zhuo, Y.; Chai, Y.Q.*; Yuan, R.*. Ultrasensitive electrochemical immunosensor for carbohydrate antigen 19-9 using Au/porous graphene nanocomposites as platform and Au@Pd core/shell bimetallic functionalized graphene nanocomposites as signal enhancers. Biosens. Bioelectron., 2015, 66, 356-362.

19.  Zhu, Q.; Chai, Y.Q.*; Zhuo, Y.; Yuan, R.*. Ultrasensitive simultaneous detection of four biomarkers based on hybridization chain reaction and biotin-streptavidin signal amplification strategy.Biosens. Bioelectron.,2015, 68, 42-48.

20.  Wang, H.J.; Yuan, Y.L.; Chai, Y.Q.*; Yuan, R.*. Self-enhanced electrochemiluminescence immunosensor based on nanowires obtained by a green approach.Biosens. Bioelectron.,2015, 68, 72-77.

21.  Yang, Z.H.; Zhuo, Y.; Yuan, R*; Chai, Y.Q.*. An amplified electrochemical immunosensor based on in situ-produced 1-naphthol as electroactive substance and graphene oxide and Pt nanoparticles functionalized CeO2 nanocomposites as signal enhancer.Biosens. Bioelectron., 2015, 69, 321-327.

22.  Wang, J.X.; Zhuo, Y.; Zhou, Y.; Yuan, R.*; Chai, Y.Q.*. Electrochemiluminescence immunosensor based on multifunctional luminol-capped AuNPs@Fe3O4 nanocomposite for the detection of mucin-1.Biosens. Bioelectron., 2015, 71, 407-413.

23.  Zhang, L; He, Y; Wang, H.J.; Yuan, Y.L.; Yuan, R*; Chai, Y.Q*. A self-enhanced electrochemiluminescence immunosensor based on l-Lys-Ru(dcbpy)32+ functionalized porous six arrises column nanorods for detection of CA15-3.Biosens. Bioelectron.,2015,74, 924-930.

24.  Gui, GF; Zhuo, Y; Chai, YQ*; Xiang, Y; Yuan, R*. A novel ECL biosensor for beta-lactamase detection: Using Ru(II) linked-ampicillin complex as the recognition element.Biosens. Bioelectron.,2015, 70, 221-225.

25.  Liu, YT; Zhang, QQ; Wang, HJ; Yuan, YL; Chai, YQ*; Yuan, R*. An electrochemiluminescence immunosensor for thyroid stimulating hormone based on polyamidoamine-norfloxacin functionalized Pd-Au core-shell hexoctahedrons as signal enhancers. Biosens. Bioelectron.,2015, 71, 164-170.

26.  Zhang, J.; Yuan, Y.L.; Xie, S.B.; Chai, Y.Q.*, Yuan, R.*.Amplified amperometric aptasensor for selective detection of protein using catalase-functional DNA-PtNPs dendrimer as a synergetic signal amplification label. Biosens. Bioelectron.,2014, 60, 224-230.

27.  Wang, H.J.; Yuan, R.*; Chai, Y.Q.*; Cao, Y.L.; Gan, X.X.; Chen, Y.F.; Wang, Y.. An ultrasensitive peroxydisulfate electrochemiluminescence immunosensor for Streptococcus suis serotype 2 based on L-cysteine combined with mimicking bi-enzyme synergetic catalysis to in situ generate coreactant. Biosens. Bioelectron., 2013, 4363-68.

28.  Zhu, Q.; Chai, Y.Q.*; Yuan, R.*; Zhuo, Y.; Han, J.; Li, Y.; Liao, N.. Amperometric immunosensor for simultaneous detection of three analytes in one interface using dual functionalized graphene sheets integrated with redox-probes as tracer matrixes. Biosens. Bioelectron.,2013, 43,440-445.

29.  Bai, L.J.; Chai, Y.Q.*; Yuan, R.*; Yuan, Y.L.; Xie, S.B.; Jiang, L.P. Amperometric aptasensor for thrombin detection using enzyme-mediated direct electrochemistry and DNA-based signal amplification strategy. Biosens. Bioelectron., 2013, 50, 325-330.

30.  He, Y.; Chai, Y.Q.*; Yuan, R.*; Wang, H.J.; Bai, L.J.; Cao, Y.L.; Yuan, Y.L..An ultrasensitive electrochemiluminescence immunoassay based on supersandwich DNA structure amplification with histidine as a co-reactant. Biosens. Bioelectron., 2013, 50, 294-299.