English  |  
当前位置:首页 > 学院总览 > 师资信息 > 正文
官智
发布时间: 2015-12-22 14:18:35   作者:本站编辑   来源: 本站原创   浏览次数:

官 智

工作经历

2015 目前      研究员,博士生导师,西南大学化学化工学院。

2005 - 2012       特聘教授,重庆市第二届学术技术带头人后备人选,西南大        学化学化工学院

2003 – 2005      研究助理,英国伦敦大学Birkbeck 学院生物和化学科学系,以及Exeter 大学生物和化学科学系

2002 -  2003      博士后,瑞典Uppsala 大学有机化学系

2000 – 2002      博士后,瑞典Lund 大学分子生物物理系

1988 – 1994      研究实习员,云南省热带作物科学研究所

教育背景

1997 – 2000   博士研究生,中山大学化学化工学院有机化学系

1994 – 1997   硕士研究生,中山大学化学化工学院有机化学系

1984 – 1988   本科,云南大学化学系

1991 – 1992   西安外国语学院出国人员外语强化部

研究兴趣

有机化合物的生物转化/生物催化、有机氟化物的合成方法、不对称催化、绿色合成方法学、仿生合成。

主持科研项目

国家自然科学基金面上项目:酶的非天然催化功能:非水介质中酶催化的不对称Mannich反应及机理研究,2013.01-2016.12

国家自然科学基金面上项目:基于金属导向的自组装金属-酶超分子不对称催化构建C-C键及机理研究,2015.01-2018.12

重庆市自然科学基金重点项目:蛋白质与有机小分子相互作用的应用研究—基于功能的蛋白酪氨酸磷酸酶(PTPs)的富集分离研究,2010.01-2012.12

人事部留学人员科技活动择优资助项目:磷酸酶有机抑制剂的设计、合成及应用研究,2009.08-2010.07

教育部留学回国人员科研启动基金:蛋白磷酸酶PTPs含氟有机小分子抑制剂的设计、合成和应用研究,2006.09-2008.08

重庆市自然科学基金一般项目:磷酸蛋白酶PTPs活性探针库的合成研究, 2006.08-2008.07

代表论文

1.   Bennett, Matthew; Guan, Zhi; Laurberg, Martin; Su, Xiaodong*. Bacillus subtilis Arsenate Reductase is Structurally and Functionally Similar to Low-molecular-weight Protein Tyrosine Phosphatases (PTPs)Proceedings of the National Academy of Sciences of the United States of America (PNAS), 2001, 98(24), 13577-13582.

2. Yang Yang; Yan-Hong He; Zhi Guan*; Wei-Da Huang. A Highly Efficient Large-scale Asymmetric Direct Intermolecular Aldol Reaction Employing L-Prolinamide as a Recoverable Catalyst. Advanced Synthesis & Catalysis. 2010, 352, 2579-2587.

3. Hai-Hong Li; Yan-Hong He; Yi Yuan; Zhi Guan*. Nuclease p1: A New Biocatalyst for Direct Asymmetric Aldol Reaction under Solvent-free Conditions. Green Chemistry. 2011, 13 (1), 185-189.

4. Ling-Po Li, Xin Cai, Yang Xiang, Yong Zhang, Jian Song, Da-Cheng Yang, Zhi Guan* Yan-Hong He*. a-Chymotrypsin-catalyzed Povarov reaction: one-pot synthesis of tetrahydroquinoline derivatives. Green Chemistry, 2015, 17 (5), 3148-3156.

5. Yan-Hong He, Hai-Hong Li, Yan-Li Chen, Yang Xue, Yi Yuan, Zhi Guan*. Chymopapain-catalyzed Direct Asymmetric Aldol Reaction. Advanced Synthesis & Catalysis, 2012, 354 (4), 712-719.

5. Zhi Guan, Yan-Li Chen,Yi Yuan, Jian Song, Da-Cheng Yang, Yang Xue, Yan-Hong He*.    Earthworm is a versatile and sustainable biocatalyst for organic synthesis. PLoS ONE, 2014, 9(8): e105284. doi:10.1371/journal.pone.0105284

6. Yang Xue, Ling-Po Li, Yan-Hong He*, Zhi Guan*. Protease-catalysed Direct Asymmetric Mannich Reaction in Organic Solvent. Scientific Reports, 2012, 2, 761; DOI:10.1038/srep00761.

7. Yan-Hong He*, Wen Hu, Zhi Guan*. Enzyme-catalyzed direct three-component aza-Diels-Alder reaction using hen egg white lysozyme. The Journal of Organic Chemistry, 2012, 77 (1), 200−207.

8. Hai-Hong Li; Yan-Hong He; Zhi Guan*. Protease-catalyzed Direct Aldol Reaction. Catalysis Communications. 2011, 12, 580-582.

9. Ying Hu; Yan-Hong He; Zhi Guan*. A Simple Method for the Preparation of Functionalized Trisubstituted Alkenes and a,b,g,d-Unsaturated Carbonyl Compounds by Using Natural Amino Acid L-Tryptophan. Catalysis Communications. 2010, 11(7), 656-659.

10. Tao He, Qing-Qing Zeng, Da-Cheng Yang, Yan-Hong He*, Zhi Guan*. Biocatalytic one-pot three-component synthesis of 3,3’-disubstituted oxindoles and spirooxindole pyrans using α-amylase from hog pancreas. RSC Advances, 2015, 5 (47), 37843-37852.

11. Ling-Yu Li, Da-Cheng Yang, Zhi Guan*, Yan-Hong He*. Pepsin-catalyzed direct asymmetric aldol reactions for the synthesis of vicinal diol compounds. Tetrahedron, 2015, 71 (11), 1659-1667.

12. Zhi Guan*, Ling-Yu Li, Yan-Hong He*. Hydrolase-catalyzed asymmetric carbon-carbon bond formation in organic synthesis. RSC Advances, 2015, 5 (22), 16801-1681.

13. Zhi Guan*, Jian Song, Yang Xue, Da-Cheng Yang, Yan-Hong He*. Enzyme-catalyzed asymmetric Mannich reaction using acylase from Aspergillus melleus. Journal of Molecular Catalysis B: Enzymatic, 2015, 111, 16-20.

14. Yan-Hong He*, Jian Song, Da-Cheng Yang, Zhi Guan*. Catalytic earthworms: in three-component cascade Mannich-Michael reactions. Tetrahedron, 2015, 71 (33), 5248-5253.

15. Ling-Yu Li, Qing-Qing Zeng, Ya-Xuan Yang, Hong-Feng Hu, Man Xu, Zhi Guan*, Yan-Hong He*. A domino reaction for the synthesis of 2-amino-4H-chromene derivatives using bovine serum albumin as a catalyst.  Journal of Molecular Catalysis B: Enzymatic, 2015, 122, 1-7.

16. Yan-Hong He*, Jian-Fei Cao, Rui Li, Yang Xiang, Da-Cheng Yang, Zhi Guan*. L-proline-catalyzed multicomponent synthesis of 3-indole derivatives. Tetrahedron, 2015, 71(49), 9299-9306.

17. Guan, Zhi; Hederstedt, Lars; Li, Jinping; Su, Xiaodong. Preparation and Crystallization of a Bacillus subtilis Arsenate Reductase, Acta Cryst. D57, (UK), 2001, 1718-1721.

18. Di Wu, Yanhong He, Rongchang Tang, Zhi Guan. The First Synthesis of Diethyl a,a-Chlorofluorobenzylphosphonates. SYNLETT, 2009, (13), 2180-2182.

19. Jian Song, Jamia Moss, Da-Cheng Yang, Zhi Guan*, Yan-Hong He*. Catalyst-free synthesis of trisubstituted tetrahydrothiophenes in water via a cascade sulfa-Michale/aldol (Henry) type reaction. RSC Advances, 2014, 4(96), 54032-54038.

20. Zhi Guan*, Yuan Luo, Bao-Qiang Zhang, Krystal Heinen, Da-Cheng Yang, Yan-Hong He*. The application of a structurally simple, recyclable and large-scale L-prolinamide catalyst for asymmetric aldol reactions. Tetrahedron: Asymmetry, 2014, 25 (10-11), 802-812.

21. Bao-Qiang Zhang,Yuan Luo, Yan-Hong He*, and Zhi Guan*. Highly efficient synthesis of polysubstituted 1,2-dihydroquinolines via cascade reaction of α-ketoesters with arylamines mediated by iodine. Tetrahedron, 2014, 70(11), 1961-1966.

22. Jian-Ping Fu, Na Gao, Yang Yang, Zhi Guan*, Yan-Hong He*. Ficin-catalyzed asymmetric aldol reactions of heterocyclic ketones with aldehydes. Journal of Molecular Catalysis B: Enzymatic, 2013, 97, 1-4.

23. Na Gao, Yan-Li Chen, Yan-Hong He*, Zhi Guan*. Highly Efficient and Large-scalable Glucoamylase-catalyzed Henry Reactions. RSC Advances, 2013, 3(37), 16850-16856.

24. Yuan Yi, Guan Zhi*, He Yan Hong*. Biocatalytic direct asymmetric aldol reaction using proteinase from Aspergillus melleus. Science China Chemistry, 2013, 56(7), 939-944.

25. Jun Zhong, Zhi Guan*, Yan-Hong He*. A novel organocatalyst for direct asymmetric Michael addition of cyclohexanone to      nitroolefins. Catalysis Communications, 2013, 32, 18-22.

26. Yan-Li Chen, Wei Li, Yan Liu, Zhi Guan*, Yan-Hong He*. Trypsin-catalyzed direct asymmetric aldol reaction.        Journal of Molecular Catalysis B: Enzymatic, 2013, 87, 83-87.

27. Bang-Hua Xie, Zhi Guan, Yan-Hong He*. Promiscuous Enzyme-catalyzed Michael Addition: Synthesis of Warfarin and Derivatives. Journal of Chemical Technology & Biotechnology, 2012, 87, 1709-1714.

28. Shi-Hua Song, Jun Zhong, Yan-Hong He* and Zhi Guan*. One-pot four-component synthesis of 1H-pyrazolo[1,2-b]phthalazine-5,10-dione derivatives. Tetrahedron Letters, 2012, 53(52), 7075-7077.

29. Zhi Guan*, Jian-Ping Fu, Yan-Hong He*. Biocatalytic promiscuity: lipase-catalyzed asymmetric aldol reaction of heterocyclic ketones with aldehydes, Tetrahedron letters, 2012, 53(37), 4959-4961.

30. Bang-Hua Xie, Zhi Guan, Yan-Hong He*. Biocatalytic Knoevenagel reaction using alkaline proteinase from Bacillus licheniformis. Biocatalysis and Biotransformation, 2012, 30(2), 238-244.

31. Bang-Hua Xie, Wei Li, Yan Liu, Hai-Hong Li, Zhi Guan*, Yan-Hong He*. The enzymatic asymmetric aldol reaction using acidic protease from Aspergillus usamii. Tetrahedron, 2012, 68(15), 3160-3164.

32. Wen Hu, Zhi Guan*, Xiang Deng, Yan-Hong He*. Enzyme Catalytic Promiscuity: The Papain-catalyzed Knoevenagel Reaction. Biochimie, 2012, 94 (3), 656-661.

33.  Rong-Chang Tang, Zhi Guan, Yan-Hong He and Wen Zhu. Enzyme-Catalyzed Henry (Nitroaldol) Reaction. Journal of Molecular Catalysis B: Enzymatic, 2010, 63, 62-67.

34.  Jian-Feng Cai; Zhi Guan; Yan-Hong He*. The Lipase-catalyzed Asymmetric C-C Michael Addition. Journal of Molecular Catalysis B: Enzymatic. 2011, 68, (3-4), 240-244.

35.  Shuai Zhao; Yan-Hong He; Di Wu; Zhi Guan*. A new general approach to 4-substituted -3-halo-2-quinolones. Journal of Fluorine Chemistry, 2010, 131, 597-605.

申请专利

1. 官智 吴狄 何延红。α, α-氟氯芳甲基膦酸酯及其制备方法。2009,中国专利申请号:200910103270.4

2. 官智 何延红 胡颖。L-色氨酸作为Knoevenagel反应催化剂的应用。2009,中国专利申请号:200910104709.6

3. 官智 何延红 赵帅。4-取代-3--2-喹诺酮的合成方法。2010,中国专利申请号:201010042090.2

4. 官智 何延红 赵帅。4-取代-3--2-喹诺酮的合成方法。2010,中国专利申请号:201010042091.7

5. 官智 何延红 赵帅。4-取代-3--2-喹诺酮的合成方法。2010,中国专利申请号:201010042092.1

6. 官智 何延红 杨阳。L-脯氨酰胺衍生物及其制备方法和应用。2010,中国专利申请号:201010203547.3

7. 官智 何延红 吴狄。氟代双苯磺酰亚胺作为氮杂Diels-Alder反应催化剂的应用。2010,中国专利申请号:201010129107.8

8. 官智 何延红 蔡建峰。固定化脂肪酶Lipozyme TLIM作为不对称Michael加成反应催化剂的应用。2010,中国专利申请号:201010201185.4

9. 官智 何延红 胡颖。L-精氨酸在以离子液体为介质的Knoevenagel反应中作为催化剂的应用。2009,中国专利申请号:200910191236.7

10. 官智 何延红 胡颖。α,β,γ,δ-不饱和羰基化合物的合成方法。2009,中国专利申请号:200910191235.2

 

欢迎报考课题组的硕士或博士研究生(包括保送生和调剂生)。

Email: guanzhi@swu.edu.cn

Tel: 023-68254091